Cascade.UKMLA physiology, simulated
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Live physiology · 14 systems · UKMLA

Can you treat this patient before they deteriorate?

Every drug changes the whole patient, and every decision costs them minutes. Try it below, no account needed.

Acute severe asthmaKnown asthmatic · can't finish sentences
Minute 0 of 306 moves left

· A short version of a real Daily case. The full Daily gives you all 34 treatments →

The clock is the patient's, not yours. Every treatment costs simulated minutes, and anything time-critical that is late lets the physiology drift.
How it works

One change, followed all the way down.

What you just tried is one condition in one playground. Each playground is a live model you can load with any of its conditions and prescribe into, with the UK guideline beside it.

  1. 01
    Load a condition

    Pick a system and a preset patient. Their physiology starts deranged the way that condition really derails it.

  2. 02
    Prescribe into it

    Every drug button is a real intervention with a real mechanism. Stack them, and the interactions show up too.

  3. 03
    Watch it cascade

    Each downstream value moves, with a note on why, and the UK guideline for that step is right there to check against.

Guideline panelBTS/SIGN 158

Acute severe asthma

  • Any one of: PEF 33–50% of best, RR ≥25/min, HR ≥110/min, can't complete sentences in one breath.
  • Oxygen to keep SpO₂ 94–98%.
  • Salbutamol 5 mg via oxygen-driven nebuliser, repeated at 15–30 minute intervals if needed.
  • Add ipratropium 0.5 mg nebulised.
  • Prednisolone 40–50 mg daily for at least 5 days.
  • Poor initial response: consider a single dose of IV magnesium sulfate 1.2–2 g over 20 minutes, after senior discussion.

Summarised from BTS/SIGN 158. In the playground, every condition has its own panel quoting and citing its guideline.

Inside

Drawn accurately, and every one of them runs.

All fourteen playgrounds, each one a live model you can prescribe into.

All 14 run in your browser, from neonates to the eye. A free account opens every playground.

Create a free account
Why Cascade

Keep your question bank. Cascade is why the answers stick.

A question bank tells you which answer is right. Cascade shows you what every answer does to the patient, and in our Qbank your answer decides the next question. Try it: pick any option, including the wrong ones.

In a question bankSingle best answer

A 68-year-old man with heart failure, on ramipril and spironolactone and recently started on trimethoprim, has a potassium of 7.1 mmol/L. His ECG shows tall tented T waves, absent P waves and a broad QRS. What is the most appropriate immediate management?

Pick an answer.

In the playgroundUKKA 2026

The same patient, the next 30 minutes

ECG: peaked T waves, broad QRS

Pick an answer on the left and watch what it does to his potassium and his ECG.

Simplified for this page. The full version runs live in the cardio-renal playground.

In the Cascade Qbank

Every answer has a knock-on effect.

Most question banks mark you and move on. Ours carries your answer forward: question 2 is the patient you left behind, so a wrong call becomes the problem you have to fix next.

Question 1Immediate management
    Your question 2

    Pick an answer above to see which question 2 you get.

    From Qbank case hyperkalaemia-01, question 1 shortened. Question 3 then forks again on how his potassium responds.

    Sourced

    Management mapped to UK guidance: NICE, BTS, SIGN, UKKA, RCOG and BNF, cited beside each condition.

    Qbank

    Over 1,100 branching single-best-answer cases across sixteen systems, with new cases added every week. Every wrong answer leads somewhere real.

    Every drug

    Every prescription is open in every condition you can load. You're never stopped from trying something.

    Start free, today

    A new patient every day. Same one for everybody.

    What it costs

    One plan. Everything in it.

    Free

    £0forever
    • Today's Cascade Daily case, every day, with the full debrief
    • A free account opens every playground, with its free conditions
    • Every prescription in those conditions, with the reasoning
    • The UK guideline panel beside each condition
    • Your school on the leaderboard
    • The full condition set and the Qbank
    Play today's case

    No account needed for the daily or the leaderboard. The playgrounds need a free account.

    Cascade

    £30a year
    • Every condition in every system
    • The full Qbank, and every case added during your year
    • Unlimited practice on any past daily case
    • New systems and conditions as they land
    • Streaks, history and sync across devices
    Start free
    Questions

    Things people ask.

    Getting started

    Do I need an account?

    Not to play the daily case or look at the leaderboard. A free account opens every playground. The full condition set and the Qbank are on the £30 plan.

    What stays free forever?

    The daily case and the school leaderboard, with no account at all. With a free account: every playground, its free conditions with every prescription open, and the guideline panel.

    What is Cascade Daily?

    One patient a day, the same one for everybody. You get a fixed number of actions and a fixed number of the patient's minutes. Every drug and every investigation spends both, and the physiology drifts while you decide.

    How does the school leaderboard work?

    It ranks medical schools by the total points their students score on the daily case each week, Monday to Sunday, so a school climbs by getting more of its year playing and treating the patient well. Each school also shows how many people played and its median score. There is a second board for individuals, but you only appear on it if you switch it on and set a display name, and it never shows an email.

    Does it work on my phone?

    Yes. Cascade runs in your browser, so there is nothing to install. It works on a laptop, tablet or phone.

    Still got a question? Email support@cascade.clinic.

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    Treat the patient · no accountTry it